CardioMEMS (tm) HF System (St. Jude Medical, Inc.) and Sacubitril/Valsartan (Entresto (tm), Novartis AG) for management of congestive heart failure: effectiveness, value, and value-based price benchmarks : final report
- Collection:
- Health Policy and Services Research
- Author(s):
- Ollendorf, Daniel A., author Ollendorf, Daniel A., author Tarlochan Sandhu, Alexander, author Chapman, Rick, author Heidenreich, Paul A., author Russo, Elizabeth, author Shore, Karen K., author Synnott, Patricia, author Travers, Karin, author Weissberg, Jed, author Pearson, Steven D., author
- Contributor(s):
- California Technology Assessment Forum, issuing body. Institute for Clinical and Economic Review, issuing body.
- Publication:
- [Boston, MA] : Institute for Clinical and Economic Review, December 1, 2015
- Language(s):
- English
- Format:
- Text
- Subject(s):
- Angiotensin II Type 1 Receptor Blockers -- administration & dosage Antihypertensive Agents -- administration & dosage Blood Pressure Monitoring, Ambulatory -- instrumentation Blood Pressure Monitoring, Ambulatory -- methods Heart Failure -- diagnosis Heart Failure -- drug therapy Neprilysin -- administration & dosage Tetrazoles -- administration & dosage Valsartan -- administration & dosage Angiotensin II Type 1 Receptor Blockers -- economics Antihypertensive Agents -- economics Cost-Benefit Analysis Drug Combinations Drug Costs Neprilysin -- antagonists & inhibitors Neprilysin -- economics Outcome and Process Assessment (Health Care) Tetrazoles -- economics Valsartan -- economics Humans United States
- Genre(s):
- Technical Report
- Abstract:
- Congestive heart failure (CHF) describes the condition of fluid build-up in the body as the heart inefficiently fills with or pumps out blood. CHF results from other conditions that weaken the heart muscle including coronary artery disease, myocardial infarction, cardiomyopathy, and hypertension, and is a major public health concern. Two new interventions for CHF have received significant attention--a device and associated software for monitoring increases in pulmonary artery (PA) pressure (a key indicator of worsening CHF) known as the CardioMEMS(tm) HF System (St. Jude Medical), and a drug, Entresto(tm) (Novartis AG), a combination of the angiotensin II receptor blocker (ARB) valsartan and the neprilysin (nep-rĭ-lī-sin) inhibitor sacubitril. The objective of this report is to evaluate the accumulated evidence on these two new interventions, to understand the context around their potential use in clinical practice, and to assess their cost-effectiveness and budgetary impact. Topic in Context. In summarizing the contextual considerations for appraisal of a health care intervention, we seek to highlight the four following specific issues: (1) Is there a particularly high burden/severity of illness? (2) Do other acceptable treatments exist? (3) Are other equally or more effective treatments nearing introduction into practice? (4) Would other societal values accord substantially more or less priority to providing access to this treatment for this patient population?
- Copyright:
- Reproduced with permission of the copyright holder. Further use of the material is subject to CC BY license. (More information)
- Extent:
- 1 online resource (1 PDF file (i-vi, ES1-ES24, 108 pages))
- Illustrations:
- Illustrations
- NLM Unique ID:
- 101672986 (See catalog record)
- Permanent Link:
- http://resource.nlm.nih.gov/101672986