Annealing cDNA3' and cDNA5' to Linear ASV DNA
- Contributor(s):
- University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers UCSF
- Publication:
- Produced: [1978]
- Language(s):
- English
- Format:
- Still image
- Subject(s):
- Avian Sarcoma Viruses DNA
- Genre(s):
- Archival Materials Slides (photographs) Charts (graphic documents)
- Abstract:
- In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process.
- Copyright:
- This item may be under copyright protection; contact the copyright owner for permission before re-use.
- Extent:
- 1 pages
- NLM Unique ID:
- 101584926X132 (See in Profiles in Science)
- Profiles in Science ID:
- MVBBJQ
- Permanent Link:
- http://resource.nlm.nih.gov/101584926X132
- Archival Collection:
- The Harold Varmus Papers (Profiles in Science)