The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Kornberg, Arthur, 1918-2007
Crick, Francis, 1916-2004
Crick here discussed continued efforts to decipher the genetic code, in particular the use of base-equivalents such as bromouracil (chemically very similar to the base uracil in RNA) to induce mutations, specifically the substitution of one base by another. The second laboratory method mentioned was the synthesis of strands of RNA of known, simple, repetitive sequence (Crick here referred to poly AU) as a means of finding out which triplets of bases code for which amino acids (a sequence of AUAUAUAUA etc. codes for the polypeptide isoleucine-tyrosine-isoleucine-tyrosine etc).
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