In his letter to Klug--the second in a day, demonstrating how involved Crick remained in DNA research even after his relocation to the Salk Institute and his switch to neurobiology--Crick further speculated on the structure of DNA and its associated proteins, the histones, as it appears on the chromosomes of higher organisms. In particular he examined the idea that the nucleosomes, assemblies of DNA and histones with a regular, repeating bead-like shape, formed solenoids, or coiled, tubular structures. Crick here discussed what dimensions and symmetrical properties such solenoids would have to possess to fit the X-ray and electron microscope evidence reported by Klug and others.
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