This schematic drawing shows the sites at which restriction endonuclease cleaves, or disrupts, the interior bonds of the DNA sequence in the provirus of Avian Sarcoma Virus (the DNA form of ASV RNA produced during replication of the virus in the cell). Varmus and other scientists use restriction endonucleases extensively for sequencing DNA, for finding individual genes (including oncogenes), and for genetic recombination.
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