The third in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, Rodbell established that the glucagon receptor is involved in the activation of the enzyme adenyl cyclase and that intracellular signaling is achieved through specific GTP-binding heterotrimeric G-proteins.
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