As part of a series of articles in this collection covering Nirenberg's work on hybrid cells, the authors in this report show that clonal hybrid cells, which are known to synthesize, store and excrete acetylcholine, form synapses with striated muscle cells in vitro. The authors conclude that the ability of hybrid cells to form synapses provides opportunities to correlate aspects of synaptogenesis with the molecular basis of developmental and electrophysiological characteristics of cells.
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