This sketch provides an early outline of what Crick called the Central Dogma, the axiom that DNA and RNA specify protein, but that protein can never specify either. The Central Dogma was a succinct theory about the flow of information in living cells. Crick first publicly elaborated on the Central Dogma at a Society for Experimental Biology Symposium on "The Biological Replication of Macromolecules," held at University College London in September 1957.
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