Champe here told further of his efforts to map the rII region of the bacteriophage T2. His goal was to map changes in the mutant strain rII to changes in the amino acid sequence of the protein for which it coded. (Bacterial viruses are composed of nucleoprotein, an assembly of nucleic acid and protein, which upon infection enters the bacterial cell, where it induces the synthesis of more viral nucleoprotein.) Champ was beginning to isolate and purify parts of the polypeptide for which rII coded.. Champ's letter illustrates the degree to which research in molecular genetics depended on collaboration between laboratories across countries and across continents, on the exchange of researchers, ideas, and experimental strains.
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