Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin
Contributor(s):
Avery, Oswald Theodore, 1877-1955
Goebel, Walther Friedrich, 1899-1993
Journal of Experimental Medicine
The first of a long series of studies on efforts by Avery's lab to chemically couple the type-II and type-III pneumonia polysaccharides to protein. Although Avery oversaw most of these experiments, their principle investigator was Goebel, who in 1939, independently demonstrated that the specificity of the type-III polysaccharide is inherent in the structure of the disaccharide, glucose-glucuronic acid. When the disaccharide was coupled with the protein, it yielded a synthetic antigen that induced the formation of antibodies reactive with the intact polysaccharide. These antibodies could protect laboratory animals against type-III infection.
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