Some Relationships of Structure to Function in Ribonuclease
- Contributor(s):
- Anfinsen, Christian B. (Christian Boehmer), 1916-1995 Annals of the New York Academy of Sciences White, F. H., Jr
- Publication:
- New York Academy of Sciences, 4 September 1959
- Language(s):
- English
- Format:
- Text
- Subject(s):
- Ribonucleases Oxidation-Reduction Protein Conformation Disulfides
- Genre(s):
- Archival Materials Articles
- Abstract:
- This study by White and Anfinsen on the renaturation of fully denatured ribonuclease, or RNase, required subsequent supporting investigations to establish what came to be called the "thermodynamic hypothesis." Here they reported that RNase activity depended upon a variety of structural features, but noted that it could be inferred from the results of their experimentation that only a small part of the enzyme molecule, what they termed the "active center," was necessary for catalyst.
- Copyright:
- This item may be under copyright protection; contact the copyright owner for permission before re-use.
- Extent:
- 9 pages
- NLM Unique ID:
- 101584571X166 (See in Profiles in Science)
- Profiles in Science ID:
- KKBBKY
- Permanent Link:
- http://resource.nlm.nih.gov/101584571X166
- Archival Collection:
- The Christian B. Anfinsen Papers (Profiles in Science)