PA-PSRS has received hundreds of Serious Event reports between June 2004 and January 2008 associated with anticoagulation therapy with outcomes having hematologic effects from thrombocytopenia to hemorrhage. The indications, dosages, strengths, and pharmacokinetics for anticoagulants are quite variable, requiring extra attention to prescribing, dispensing, administering, and monitoring the effects of these medications. The complexity of anticoagulants has resulted in patient safety compromise. Healthcare organizations have increasingly recognized the benefits of anticoagulation management services (AMS) in the inpatient and outpatient settings. The benefits of an AMS program include a reduction in mortality rates and bleeding complications, decreased adverse drug events, including medication errors and shortened hospital stays, thereby producing safer patient care. The key components in AMS program development include defining the rationale for AMS development, outlining issues associated with anticoagulants, defining AMS scope of service and infrastructure, and outlining AMS program metrics.
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