Icodextrin in peritoneal dialysis solution may cause falsely high blood glucose readings
- Collection:
- Health Policy and Services Research
- Series Title(s):
- Pennsylvania patient safety advisory
- Contributor(s):
- Pennsylvania. Patient Safety Authority. ECRI (Organization) Institute for Safe Medication Practices.
- Publication:
- [Harrisburg, Pa.] : Pennsylvania Patient Safety Authority, c2008
- Language(s):
- English
- Format:
- Text
- Subject(s):
- Blood Glucose -- analysis Blood Glucose Self-Monitoring -- instrumentation False Positive Reactions Hemodialysis Solutions Point-of-Care Systems Diagnostic Equipment Galactose -- blood Maltose -- blood Patient Education as Topic Xylose -- blood Humans Pennsylvania United States
- Genre(s):
- Technical Report
- Abstract:
- Falsely elevated blood glucose level readings can lead to incorrect treatment and, subsequently, serious patient harm or death. Blood containing certain saccharides can falsely elevate the results obtained from point-of-care (POC) glucose meters using the glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) enzyme/indicator test method. At-risk patients include peritoneal dialysis patients receiving dialysis solutions containing icodextrin, patients receiving certain types of immunoglobulin therapy, or patients receiving other drugs containing maltose, galactose, or xylose. GDH-PQQ meters cannot distinguish between maltose, galactose, or xylose contained in blood. Mitigation strategies to help facilities reduce or eliminate falsely elevated readings include educating staff and at-risk patients about the problem and becoming familiar with the enzymatic test methods used by POC glucose meters; labeling affected POC meters and contraindicating their use for patients receiving solutions containing icodextrin, maltose, galactose, or xylose; and instructing staff and at-risk patients to use POC meters not based on the GDH-PQQ method.
- Copyright:
- Reproduced with permission of the copyright holder. Further use of the material is subject to CC BY-NC-DC license. (More information)
- NLM Unique ID:
- 101569760 (See catalog record)
- Permanent Link:
- http://resource.nlm.nih.gov/101569760